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The Genetics of Aromatase Inhibitor-related Phenotypes in Postmenopausal Women with ER+ Breast Cancer

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개인저자Dudenkov, Tanda Tosia Murray.
단체저자명College of Medicine - Mayo Clinic. Molecular Pharmacology and Experimental Therapeutics.
서명/저자사항The Genetics of Aromatase Inhibitor-related Phenotypes in Postmenopausal Women with ER+ Breast Cancer.
발행사항[S.l.] : College of Medicine - Mayo Clinic., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항257 p.
소장본 주기School code: 1542.
ISBN9780438272019
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Richard M. Weinshilboum.
요약Breast cancer is the most common invasive cancer diagnosed in women worldwide, and is responsible for more than 230,000 annual deaths in the United States. Early stage breast tumors are sub-classified based on their hormone receptor status, with
요약Anastrozole is a non-steroidal, reversible, competitive inhibitor of aromatase, and is the most commonly prescribed AI in the United States. However, it is universally administered in only one dose, 10 mg/day, without regard for pre-treatment es
요약As an initial step towards achieving these goals, the first part of this dissertation sought to fill the vacuum of knowledge concerning genetic contributors to variation in plasma concentrations of hormones in the estrone biosynthesis pathway in
요약The second part of this dissertation focused on the discovery of genetic determinants of plasma anastrozole concentrations and the application of those variants in predicting tangible clinical outcomes in postmenopausal women with ER+ breast can
일반주제명Genetics.
Pharmacology.
Oncology.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996631

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