| LDR | | 02463nmm uu200457 4500 |
| 001 | | 000000334638 |
| 005 | | 20240805180718 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438272019 |
| 035 | |
▼a (MiAaPQ)AAI10615538 |
| 035 | |
▼a (MiAaPQ)mayo:10451 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Dudenkov, Tanda Tosia Murray. |
| 245 | 14 |
▼a The Genetics of Aromatase Inhibitor-related Phenotypes in Postmenopausal Women with ER+ Breast Cancer. |
| 260 | |
▼a [S.l.] :
▼b College of Medicine - Mayo Clinic.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 257 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Richard M. Weinshilboum. |
| 502 | 1 |
▼a Thesis (Ph.D.)--College of Medicine - Mayo Clinic, 2017. |
| 520 | |
▼a Breast cancer is the most common invasive cancer diagnosed in women worldwide, and is responsible for more than 230,000 annual deaths in the United States. Early stage breast tumors are sub-classified based on their hormone receptor status, with |
| 520 | |
▼a Anastrozole is a non-steroidal, reversible, competitive inhibitor of aromatase, and is the most commonly prescribed AI in the United States. However, it is universally administered in only one dose, 10 mg/day, without regard for pre-treatment es |
| 520 | |
▼a As an initial step towards achieving these goals, the first part of this dissertation sought to fill the vacuum of knowledge concerning genetic contributors to variation in plasma concentrations of hormones in the estrone biosynthesis pathway in |
| 520 | |
▼a The second part of this dissertation focused on the discovery of genetic determinants of plasma anastrozole concentrations and the application of those variants in predicting tangible clinical outcomes in postmenopausal women with ER+ breast can |
| 590 | |
▼a School code: 1542. |
| 650 | 4 |
▼a Genetics. |
| 650 | 4 |
▼a Pharmacology. |
| 650 | 4 |
▼a Oncology. |
| 690 | |
▼a 0369 |
| 690 | |
▼a 0419 |
| 690 | |
▼a 0992 |
| 710 | 20 |
▼a College of Medicine - Mayo Clinic.
▼b Molecular Pharmacology and Experimental Therapeutics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 1542 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996631
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |