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Computational Insights into the Antimicrobial Mechanism of Action of Class II Bacteriocins

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개인저자Kyriakou, Panagiota.
단체저자명University of Minnesota. Chemical Engineering.
서명/저자사항Computational Insights into the Antimicrobial Mechanism of Action of Class II Bacteriocins.
발행사항[S.l.] : University of Minnesota., 2017
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항148 p.
소장본 주기School code: 0130.
ISBN9780438170339
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Yiannis Kaznessis.
요약Antibiotic resistance is a global problem and poses an alarming threat to public health. Microorganisms resistant to all commercially available antibiotics have emerged, undermining the ability to fight infectious diseases. The antibiotic resist
요약Bacteriocins are bacteria-produced, antimicrobial peptides that are potentially powerful antibiotic drug candidates. Despite considerable scientific interest around bacteriocins, and despite their promise as potent, latent antibiotics, their eve
요약First, we studied Plantaricin EF, a two-peptide class IIb bacteriocin. This bacteriocin was simulated in different environments including water, micelles, and lipid bilayers. The interaction between the two peptides that promotes dimerization, a
요약It is not unlikely that the mechanism of action of bacteriocins can involve poration of the membrane as well as receptor-mediation. Therefore, the interaction of a bacteriocin with its putative receptor was also examined. Lacking the structure o
요약We believe that our findings could be of importance to the designing of new antibiotic agents, as it would guide the search for better bacteriocins toward peptides with improved activity and specificity, that form stable pores, increase water or
일반주제명Biophysics.
Molecular biology.
Chemical engineering.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14996593

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