| LDR | | 00000nmm u2200205 4500 |
| 001 | | 000000334600 |
| 005 | | 20250123115334 |
| 008 | | 181129s2017 ||| | | | eng d |
| 020 | |
▼a 9780438170339 |
| 035 | |
▼a (MiAaPQ)AAI10286019 |
| 035 | |
▼a (MiAaPQ)umn:18161 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 049 | 1 |
▼f DP |
| 082 | 0 |
▼a 574.191 |
| 100 | 1 |
▼a Kyriakou, Panagiota. |
| 245 | 10 |
▼a Computational Insights into the Antimicrobial Mechanism of Action of Class II Bacteriocins. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 148 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Yiannis Kaznessis. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2017. |
| 520 | |
▼a Antibiotic resistance is a global problem and poses an alarming threat to public health. Microorganisms resistant to all commercially available antibiotics have emerged, undermining the ability to fight infectious diseases. The antibiotic resist |
| 520 | |
▼a Bacteriocins are bacteria-produced, antimicrobial peptides that are potentially powerful antibiotic drug candidates. Despite considerable scientific interest around bacteriocins, and despite their promise as potent, latent antibiotics, their eve |
| 520 | |
▼a First, we studied Plantaricin EF, a two-peptide class IIb bacteriocin. This bacteriocin was simulated in different environments including water, micelles, and lipid bilayers. The interaction between the two peptides that promotes dimerization, a |
| 520 | |
▼a It is not unlikely that the mechanism of action of bacteriocins can involve poration of the membrane as well as receptor-mediation. Therefore, the interaction of a bacteriocin with its putative receptor was also examined. Lacking the structure o |
| 520 | |
▼a We believe that our findings could be of importance to the designing of new antibiotic agents, as it would guide the search for better bacteriocins toward peptides with improved activity and specificity, that form stable pores, increase water or |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Biophysics. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Chemical engineering. |
| 690 | |
▼a 0786 |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0542 |
| 710 | 20 |
▼a University of Minnesota.
▼b Chemical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996593
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자
▼b 관리자 |