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A Role for betacyto- and gammacyto-Actin at the Sarco/endoplasmic Reticulum-Mitochondrial Interface

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자료유형	E-Book
개인저자	O'Rourke, Allison Rose.
단체저자명	University of Minnesota. Molecular, Cellular, Developmental Biology and Genetics.
서명/저자사항	A Role for betacyto- and gammacyto-Actin at the Sarco/endoplasmic Reticulum-Mitochondrial Interface.
발행사항	[S.l.] : University of Minnesota., 2017
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2017
형태사항	149 p.
소장본 주기	School code: 0130.
ISBN	9780438170322
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: James M. Ervasti.
요약	Skeletal muscle accounts for 40% of mass in adult humans. The primary function of skeletal muscle is to produce movement via contraction of the sarcomere. The sarcomere is the basic functional until of skeletal muscle and two of the key componen
요약	As may be predicted by their ubiquitous expression patterns, beta cyto- and gammacyto actin, are enmeshed in a wide array of cellular functions including, migration, cell shape, cell division, vesicle trafficking, and organelle anchoring among o
요약	The lethal nature of whole body knockouts of either cytoplasmic actin isoform made studies into tissue specific phenotypes difficult. One tissue of interest was skeletal muscle, because of the role cytoplasmic actins have in linking the sarcomer
요약	My thesis advances understanding for how ablation of cytoplasmic actin isoforms leads to a mild myopathy. Firstly, I showed that both beta cyto- and gammacyto actin isoforms were present at the interface between mitochondria and sarcoplasmic ret
요약	Though cytoplasmic actin isoforms have been localized to an array of structures in skeletal muscle, we chose to focus on two organelles which can affect cell viability. Further investigation into the source of the observed progressive myopathy r
요약	As mitochondria are a central regulator of cell health and because of the effect we observed betacyto- and gammacyto actin have on mitochondrial dynamics, we initially hypothesized that mitochondria would be mildly functionally impaired. However
일반주제명	Cellular biology. Biochemistry. Molecular biology.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14996592