| LDR | | 02961nmm uu200481 4500 |
| 001 | | 000000334599 |
| 005 | | 20240805180630 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438170322 |
| 035 | |
▼a (MiAaPQ)AAI10285971 |
| 035 | |
▼a (MiAaPQ)umn:18159 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a O'Rourke, Allison Rose. |
| 245 | 12 |
▼a A Role for betacyto- and gammacyto-Actin at the Sarco/endoplasmic Reticulum-Mitochondrial Interface. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 149 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: James M. Ervasti. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2017. |
| 520 | |
▼a Skeletal muscle accounts for 40% of mass in adult humans. The primary function of skeletal muscle is to produce movement via contraction of the sarcomere. The sarcomere is the basic functional until of skeletal muscle and two of the key componen |
| 520 | |
▼a As may be predicted by their ubiquitous expression patterns, beta cyto- and gammacyto actin, are enmeshed in a wide array of cellular functions including, migration, cell shape, cell division, vesicle trafficking, and organelle anchoring among o |
| 520 | |
▼a The lethal nature of whole body knockouts of either cytoplasmic actin isoform made studies into tissue specific phenotypes difficult. One tissue of interest was skeletal muscle, because of the role cytoplasmic actins have in linking the sarcomer |
| 520 | |
▼a My thesis advances understanding for how ablation of cytoplasmic actin isoforms leads to a mild myopathy. Firstly, I showed that both beta cyto- and gammacyto actin isoforms were present at the interface between mitochondria and sarcoplasmic ret |
| 520 | |
▼a Though cytoplasmic actin isoforms have been localized to an array of structures in skeletal muscle, we chose to focus on two organelles which can affect cell viability. Further investigation into the source of the observed progressive myopathy r |
| 520 | |
▼a As mitochondria are a central regulator of cell health and because of the effect we observed betacyto- and gammacyto actin have on mitochondrial dynamics, we initially hypothesized that mitochondria would be mildly functionally impaired. However |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a University of Minnesota.
▼b Molecular, Cellular, Developmental Biology and Genetics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996592
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |