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Determining the Mitotic Role of the RNA Binding Protein, ATX-2, in Caenorhabditis elegans
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Gnazzo, Megan M. |
| 단체저자명 | The University of Wisconsin - Madison. Genetics. |
| 서명/저자사항 | Determining the Mitotic Role of the RNA Binding Protein, ATX-2, in Caenorhabditis elegans. |
| 발행사항 | [S.l.] : The University of Wisconsin - Madison., 2017 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| 형태사항 | 164 p. |
| 소장본 주기 | School code: 0262. |
| ISBN | 9780438373846 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Ahna Skop. |
| 요약 | Cell division is a cellular process utilized by organisms for development, tissue repair and reproduction. It involves partitioning genetic material from one cell into two cells. Failures in cell division can lead to cancer and cell death. Cell |
| 요약 | In this dissertation, I characterized the role of the RNA-binding protein, ATX-2, in cell division. The mammalian homolog of ATX-2, Ataxin-2, was originally identified in a proteomic screen of isolated mammalian midbodies. My work determined tha |
| 요약 | Lastly, I found that ATX-2 exhibits a unique ER phenotype in embryonic development. Depletion of ATX-2 results in a complete collapse of the ER tubules and causes sheets to form within the cell, and ER tubules are shortened. Interestingly, the h |
| 요약 | Taken together, my work describes the role of ATX-2 in cell division and provides insight into possible SCA2 disease mechanisms. As an RNA-binding protein, ATX-2 may orchestrate a unique function connecting the regulation of RNAs, ER dynamics, a |
| 일반주제명 | Genetics. Cellular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14996577 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028911 | 575 | 가야대학교// | 대출가능 |
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