| LDR | | 02349nmm uu200433 4500 |
| 001 | | 000000334584 |
| 005 | | 20240805180612 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438373846 |
| 035 | |
▼a (MiAaPQ)AAI10279172 |
| 035 | |
▼a (MiAaPQ)wisc:14355 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 575 |
| 100 | 1 |
▼a Gnazzo, Megan M. |
| 245 | 10 |
▼a Determining the Mitotic Role of the RNA Binding Protein, ATX-2, in Caenorhabditis elegans. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 164 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Ahna Skop. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017. |
| 520 | |
▼a Cell division is a cellular process utilized by organisms for development, tissue repair and reproduction. It involves partitioning genetic material from one cell into two cells. Failures in cell division can lead to cancer and cell death. Cell |
| 520 | |
▼a In this dissertation, I characterized the role of the RNA-binding protein, ATX-2, in cell division. The mammalian homolog of ATX-2, Ataxin-2, was originally identified in a proteomic screen of isolated mammalian midbodies. My work determined tha |
| 520 | |
▼a Lastly, I found that ATX-2 exhibits a unique ER phenotype in embryonic development. Depletion of ATX-2 results in a complete collapse of the ER tubules and causes sheets to form within the cell, and ER tubules are shortened. Interestingly, the h |
| 520 | |
▼a Taken together, my work describes the role of ATX-2 in cell division and provides insight into possible SCA2 disease mechanisms. As an RNA-binding protein, ATX-2 may orchestrate a unique function connecting the regulation of RNAs, ER dynamics, a |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Genetics. |
| 650 | 4 |
▼a Cellular biology. |
| 690 | |
▼a 0369 |
| 690 | |
▼a 0379 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Genetics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14996577
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |