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Intrinsic Mechanisms Regulating T Cell Tolerance in Autoimmune Diabetes
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Zhang, Qianxia. |
| 단체저자명 | University of Pittsburgh. |
| 서명/저자사항 | Intrinsic Mechanisms Regulating T Cell Tolerance in Autoimmune Diabetes. |
| 발행사항 | [S.l.] : University of Pittsburgh., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 171 p. |
| 소장본 주기 | School code: 0178. |
| ISBN | 9780438364943 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Dario A. A. Vignali. |
| 요약 | Type 1 Diabetes (T1D) is a polygenic autoimmune disease characterized by immune cell infiltration into the islets of Langerhans, destruction of insulin-producing beta cells, and uncontrolled hyperglycemia. Islet-antigen reactive CD4+ and CD8+ T |
| 요약 | Lymphocyte Activation Gene 3 (LAG3, CD223), a co-inhibitory receptor highly expressed on T cells, is one of these essential mechanisms that intrinsically regulate T cell tolerance in autoimmune diabetes. I evaluate the role of LAG3 on T cells ve |
| 요약 | In addition to dissecting the role of LAG3 in regulating T cell tolerance, I also show that removal of programmed death protein 1 (PD1) or overexpression of Neuropilin 1 (Nrp1) on Tregs protect NOD mice from autoimmune diabetes in Appendix A and |
| 일반주제명 | Immunology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15001403 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028771 | 616.079 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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