| LDR | | 01944nmm uu200385 4500 |
| 001 | | 000000334444 |
| 005 | | 20240805180320 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438364943 |
| 035 | |
▼a (MiAaPQ)AAI10984435 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Zhang, Qianxia. |
| 245 | 10 |
▼a Intrinsic Mechanisms Regulating T Cell Tolerance in Autoimmune Diabetes. |
| 260 | |
▼a [S.l.] :
▼b University of Pittsburgh.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 171 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Dario A. A. Vignali. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Pittsburgh, 2018. |
| 520 | |
▼a Type 1 Diabetes (T1D) is a polygenic autoimmune disease characterized by immune cell infiltration into the islets of Langerhans, destruction of insulin-producing beta cells, and uncontrolled hyperglycemia. Islet-antigen reactive CD4+ and CD8+ T |
| 520 | |
▼a Lymphocyte Activation Gene 3 (LAG3, CD223), a co-inhibitory receptor highly expressed on T cells, is one of these essential mechanisms that intrinsically regulate T cell tolerance in autoimmune diabetes. I evaluate the role of LAG3 on T cells ve |
| 520 | |
▼a In addition to dissecting the role of LAG3 in regulating T cell tolerance, I also show that removal of programmed death protein 1 (PD1) or overexpression of Neuropilin 1 (Nrp1) on Tregs protect NOD mice from autoimmune diabetes in Appendix A and |
| 590 | |
▼a School code: 0178. |
| 650 | 4 |
▼a Immunology. |
| 690 | |
▼a 0982 |
| 710 | 20 |
▼a University of Pittsburgh. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0178 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001403
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |