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Characterizing the Role of RCAN1-4 in Thyroid Cancer Growth and Metastasis
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Wang, Chaojie. |
| 단체저자명 | The Ohio State University. Biochemistry. |
| 서명/저자사항 | Characterizing the Role of RCAN1-4 in Thyroid Cancer Growth and Metastasis. |
| 발행사항 | [S.l.] : The Ohio State University., 2017 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2017 |
| 형태사항 | 148 p. |
| 소장본 주기 | School code: 0168. |
| ISBN | 9780438310117 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Matthew Ringel. |
| 요약 | Metastatic progression is the main cause of cancer-related deaths. Metastasis suppressors are proteins that inhibit metastatic progression without affecting primary tumor formation that are distinct from tumor suppressor genes. Loss of metastasi |
| 요약 | In this study, our goal is to characterize the role of RCAN1-4, the inducible RCAN1 isoform in tumor growth and metastasis using thyroid cancer models. RCAN1-4 knockdown or inducible expression thyroid cancer cell lines were established. Cell sp |
| 요약 | To study the function of RCAN1-4 in endogenous tumor models, thyroid specific RCAN1-4 inducible expression mice and thyroid specific RCAN1-4 knockout mice were also created. The mice were crossed with the DRP-TpoKO and Tg-BRAF thyroid cancer mod |
| 요약 | In summary, we have demonstrated that RCAN1-4 in the cancer cells is a tumor growth and metastasis suppressor, but not a tumor suppressor. We have also identified NFE2L3 as a potential regulator of tumor growth and metastasis in thyroid cancer t |
| 일반주제명 | Cellular biology. Biochemistry. Oncology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15001358 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028726 | 574 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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