| LDR | | 02373nmm uu200457 4500 |
| 001 | | 000000334399 |
| 005 | | 20240805180227 |
| 008 | | 181129s2017 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438310117 |
| 035 | |
▼a (MiAaPQ)AAI10970772 |
| 035 | |
▼a (MiAaPQ)OhioLINK:osu149944291867735 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Wang, Chaojie. |
| 245 | 10 |
▼a Characterizing the Role of RCAN1-4 in Thyroid Cancer Growth and Metastasis. |
| 260 | |
▼a [S.l.] :
▼b The Ohio State University.,
▼c 2017 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2017 |
| 300 | |
▼a 148 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Matthew Ringel. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Ohio State University, 2017. |
| 520 | |
▼a Metastatic progression is the main cause of cancer-related deaths. Metastasis suppressors are proteins that inhibit metastatic progression without affecting primary tumor formation that are distinct from tumor suppressor genes. Loss of metastasi |
| 520 | |
▼a In this study, our goal is to characterize the role of RCAN1-4, the inducible RCAN1 isoform in tumor growth and metastasis using thyroid cancer models. RCAN1-4 knockdown or inducible expression thyroid cancer cell lines were established. Cell sp |
| 520 | |
▼a To study the function of RCAN1-4 in endogenous tumor models, thyroid specific RCAN1-4 inducible expression mice and thyroid specific RCAN1-4 knockout mice were also created. The mice were crossed with the DRP-TpoKO and Tg-BRAF thyroid cancer mod |
| 520 | |
▼a In summary, we have demonstrated that RCAN1-4 in the cancer cells is a tumor growth and metastasis suppressor, but not a tumor suppressor. We have also identified NFE2L3 as a potential regulator of tumor growth and metastasis in thyroid cancer t |
| 590 | |
▼a School code: 0168. |
| 650 | 4 |
▼a Cellular biology. |
| 650 | 4 |
▼a Biochemistry. |
| 650 | 4 |
▼a Oncology. |
| 690 | |
▼a 0379 |
| 690 | |
▼a 0487 |
| 690 | |
▼a 0992 |
| 710 | 20 |
▼a The Ohio State University.
▼b Biochemistry. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0168 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2017 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001358
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |