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A New Biophysical Model for Translation Elongation to Predict and Optimize Heterologous Protein Production in Escherichia coli
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Vu, Scott Khoi. |
| 단체저자명 | North Carolina State University. Biomedical Engineering. |
| 서명/저자사항 | A New Biophysical Model for Translation Elongation to Predict and Optimize Heterologous Protein Production in Escherichia coli. |
| 발행사항 | [S.l.] : North Carolina State University., 2015 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2015 |
| 형태사항 | 281 p. |
| 소장본 주기 | School code: 0155. |
| ISBN | 9780438284494 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Donald L. Bitzer |
| 요약 | Translation is a biological process in which an organism produces specific polypeptides that fold into functional proteins. Heterologous protein production uses translation to synthesize proteins that are not normally expressed in production org |
| 요약 | A new computational-based biophysical model for translation elongation has been developed that provides: a) new insights into the mechanisms behind translation, e.g. elucidating programmed frameshifts prfB and dnaX, and b) a new approach to gene |
| 요약 | The model's predictive and optimization accuracy were verified by optimizing and expressing five model genes: gst (glutathione-S-transferase), pf0132 (alpha-glucosidase), clju_c11880 (alcohol dehydrogenase), bif1 (beta-galactosidase), and rt8_0 |
| 요약 | Based on the results presented in this dissertation and the literature published, the author contends that the determinants of protein yield from translation elongation are not just codon bias, but, rather, the convolution between aminoacyl-tRNA |
| 일반주제명 | Biomedical engineering. Biophysics. Molecular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15001307 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028675 | 610 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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