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Targeting Sphingolipid Metabolism in Large Granular Lymphocyte Leukemia
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | LeBlanc, Francis Roland. |
| 단체저자명 | The Pennsylvania State University. Molecular Medicine. |
| 서명/저자사항 | Targeting Sphingolipid Metabolism in Large Granular Lymphocyte Leukemia. |
| 발행사항 | [S.l.] : The Pennsylvania State University., 2016 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2016 |
| 형태사항 | 173 p. |
| 소장본 주기 | School code: 0176. |
| ISBN | 9780438135246 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
|
| 요약 | Large granular lymphocyte (LGL) leukemia is a spectrum of rare clonal lymphoproliferative disorders, all of which involve expansion of large granular lymphocytes, either cytotoxic T-lymphocytes (CTL) or natural killer (NK) cells. In normal adult |
| 요약 | In this study, we investigated sphingolipid metabolism and its role in the survival of leukemic LGLs. Sphingolipids are a group of bioactive lipids that maintain cellular integrity and can also mediate signal transduction. The balance between pr |
| 요약 | Taken together, we show that the sphingolipid metabolizing enzymes, SPHK1, SPHK2 and AC, are all important for leukemic LGL survival and are novel potential therapeutic targets. Targeting these enzymes restores the sphingolipid balance to a pro- |
| 일반주제명 | Molecular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000683 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028615 | 574 | 가야대학교// | 대출가능 |
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