| LDR | | 01958nmm uu200373 4500 |
| 001 | | 000000334288 |
| 005 | | 20240805180015 |
| 008 | | 181129s2016 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438135246 |
| 035 | |
▼a (MiAaPQ)AAI10903699 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a LeBlanc, Francis Roland. |
| 245 | 10 |
▼a Targeting Sphingolipid Metabolism in Large Granular Lymphocyte Leukemia. |
| 260 | |
▼a [S.l.] :
▼b The Pennsylvania State University.,
▼c 2016 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2016 |
| 300 | |
▼a 173 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The Pennsylvania State University, 2016. |
| 520 | |
▼a Large granular lymphocyte (LGL) leukemia is a spectrum of rare clonal lymphoproliferative disorders, all of which involve expansion of large granular lymphocytes, either cytotoxic T-lymphocytes (CTL) or natural killer (NK) cells. In normal adult |
| 520 | |
▼a In this study, we investigated sphingolipid metabolism and its role in the survival of leukemic LGLs. Sphingolipids are a group of bioactive lipids that maintain cellular integrity and can also mediate signal transduction. The balance between pr |
| 520 | |
▼a Taken together, we show that the sphingolipid metabolizing enzymes, SPHK1, SPHK2 and AC, are all important for leukemic LGL survival and are novel potential therapeutic targets. Targeting these enzymes restores the sphingolipid balance to a pro- |
| 590 | |
▼a School code: 0176. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a The Pennsylvania State University.
▼b Molecular Medicine. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0176 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2016 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000683
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |