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Folate Binding Protein as a Therapeutic Natural Nanotechnology
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Wallace, Rachel. |
| 단체저자명 | University of Michigan. Chemistry. |
| 서명/저자사항 | Folate Binding Protein as a Therapeutic Natural Nanotechnology. |
| 발행사항 | [S.l.] : University of Michigan., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 183 p. |
| 소장본 주기 | School code: 0127. |
| ISBN | 9780438125728 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Mark M. Banaszak Holl |
| 요약 | Serum proteins interact with small molecules and nanoparticles in blood, resulting in protein coronas. Protein coronas influence the bioidentity of the molecules and nanoparticles, playing critical roles in biotransport, uptake, and fate. Target |
| 요약 | The research presented here is focused on characterizing and taking advantage of a particular protein corona -- the self-aggregation of serum folate binding protein (FBP). FBP is derived from cellular folate receptors, and both bind strongly to |
| 요약 | Using atomic force microscopy (AFM), we characterized the self-aggregation of FBP on a particle-by-particle basis at physiological concentrations. FBP self-aggregates into nanoparticles (forming FBPNP) at blood serum concentrations. We further e |
| 요약 | We studied FBP aggregation with two FA-poly(amidoamine) (PAMAM) dendrimers and two FA-poly(ethylene glycol) (PEG) conjugates. Fluorescence spectroscopy experiments showed that FA and FA-conjugates induced conformational changes throughout the pr |
| 요약 | Given the challenges associated with conjugated therapies, we sought to leverage FBP itself as a targeted vector. We hypothesized that pre-binding FBP to MTX would decrease toxicity and increase therapeutic efficacy. We tested this hypothesis in |
| 일반주제명 | Inorganic chemistry. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000474 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028254 | 546 | 가야대학교// | 대출가능 |
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