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Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits

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자료유형E-Book
개인저자Donnelly, Christopher R.
단체저자명University of Michigan. Oral Health Sciences.
서명/저자사항Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits.
발행사항[S.l.] : University of Michigan., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항304 p.
소장본 주기School code: 0127.
ISBN9780438125476
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Brian Anthony Pierchala.
요약The first discovery of a growth-regulating signaling molecule was more than 65 years ago, when the work of Rita Levi-Montalcini, Viktor Hamburger, and Stanley Cohen led to the identification and purification of nerve growth factor (NGF). As the
요약This thesis work collectively sought to understand the functions of Ret signaling in peripheral nervous system development. In the first investigation (Chapter 2), we explored the function of a newly identified p75-Ret receptor complex in the de
요약In the second study (Chapter 3), we investigated the function of this p75-Ret receptor complex in developing sympathetic neurons of the superior cervical ganglion (SCG). Interestingly, p75 signaling regulates programmed cell death (PCD) during p
요약In the last study (Chapter 4), we explored the function of Ret in the development of the peripheral taste system, focusing our studies on the geniculate ganglion (GG) which afferently innervates taste buds within fungiform papillae on the anteri
일반주제명Health sciences.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000450

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