| LDR | | 02307nmm uu200409 4500 |
| 001 | | 000000333923 |
| 005 | | 20240805174807 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438125476 |
| 035 | |
▼a (MiAaPQ)AAI10902940 |
| 035 | |
▼a (MiAaPQ)umichrackham:001254 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 614 |
| 100 | 1 |
▼a Donnelly, Christopher R. |
| 245 | 10 |
▼a Neurotrophic Factor Signaling Mechanisms Underlying the Development of Peripheral Neural Circuits. |
| 260 | |
▼a [S.l.] :
▼b University of Michigan.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 304 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Brian Anthony Pierchala. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Michigan, 2018. |
| 520 | |
▼a The first discovery of a growth-regulating signaling molecule was more than 65 years ago, when the work of Rita Levi-Montalcini, Viktor Hamburger, and Stanley Cohen led to the identification and purification of nerve growth factor (NGF). As the |
| 520 | |
▼a This thesis work collectively sought to understand the functions of Ret signaling in peripheral nervous system development. In the first investigation (Chapter 2), we explored the function of a newly identified p75-Ret receptor complex in the de |
| 520 | |
▼a In the second study (Chapter 3), we investigated the function of this p75-Ret receptor complex in developing sympathetic neurons of the superior cervical ganglion (SCG). Interestingly, p75 signaling regulates programmed cell death (PCD) during p |
| 520 | |
▼a In the last study (Chapter 4), we explored the function of Ret in the development of the peripheral taste system, focusing our studies on the geniculate ganglion (GG) which afferently innervates taste buds within fungiform papillae on the anteri |
| 590 | |
▼a School code: 0127. |
| 650 | 4 |
▼a Health sciences. |
| 690 | |
▼a 0566 |
| 710 | 20 |
▼a University of Michigan.
▼b Oral Health Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0127 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000450
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |