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Functional Roles of Single Nucleotide Variants in Alternative Splicing
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Hsiao, Yun-Hua. |
| 단체저자명 | University of California, Los Angeles. Bioengineering 0288. |
| 서명/저자사항 | Functional Roles of Single Nucleotide Variants in Alternative Splicing. |
| 발행사항 | [S.l.] : University of California, Los Angeles., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 210 p. |
| 소장본 주기 | School code: 0031. |
| ISBN | 9780438078147 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Adviser: Xinshu Xiao. |
| 요약 | Next-generation sequencing has greatly facilitated large-scale analyses of the human genome. However, the function and biological significance of many single nucleotide variants, including single nucleotide polymorphisms (SNPs) and RNA editing s |
| 요약 | To tackle this question, we first developed a method to identify intronic tag SNPs that can modulate alternative splicing. The cell fractionation RNA-seq datasets from the ENCODE Project made identification of intronic SNPs possible in our metho |
| 요약 | Next, we performed a genome-wide study to uncover the interplay between individual steps of RNA processing, an essential aspect of gene regulation. In eukaryotes, nascent RNA transcripts undergo an intricate series of RNA processing steps to ach |
| 요약 | Lastly, the analyses of GMAS events in GTEx datasets provided insights into the characteristics of splicing-related SNPs and the associated exons. We observed that GMAS exons were highly tissue-specific and individual-specific, and rare GMAS eve |
| 일반주제명 | Bioinformatics. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-11B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999348 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028042 | 574 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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