| LDR | | 02293nmm uu200409 4500 |
| 001 | | 000000333715 |
| 005 | | 20240805174414 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438078147 |
| 035 | |
▼a (MiAaPQ)AAI10829803 |
| 035 | |
▼a (MiAaPQ)ucla:17044 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Hsiao, Yun-Hua. |
| 245 | 10 |
▼a Functional Roles of Single Nucleotide Variants in Alternative Splicing. |
| 260 | |
▼a [S.l.] :
▼b University of California, Los Angeles.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 210 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Adviser: Xinshu Xiao. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Los Angeles, 2018. |
| 520 | |
▼a Next-generation sequencing has greatly facilitated large-scale analyses of the human genome. However, the function and biological significance of many single nucleotide variants, including single nucleotide polymorphisms (SNPs) and RNA editing s |
| 520 | |
▼a To tackle this question, we first developed a method to identify intronic tag SNPs that can modulate alternative splicing. The cell fractionation RNA-seq datasets from the ENCODE Project made identification of intronic SNPs possible in our metho |
| 520 | |
▼a Next, we performed a genome-wide study to uncover the interplay between individual steps of RNA processing, an essential aspect of gene regulation. In eukaryotes, nascent RNA transcripts undergo an intricate series of RNA processing steps to ach |
| 520 | |
▼a Lastly, the analyses of GMAS events in GTEx datasets provided insights into the characteristics of splicing-related SNPs and the associated exons. We observed that GMAS exons were highly tissue-specific and individual-specific, and rare GMAS eve |
| 590 | |
▼a School code: 0031. |
| 650 | 4 |
▼a Bioinformatics. |
| 690 | |
▼a 0715 |
| 710 | 20 |
▼a University of California, Los Angeles.
▼b Bioengineering 0288. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0031 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999348
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |