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Stochastic Models of Epithelial Cancer Initiation and Glioblastoma Recurrence
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Storey, Kathleen M. |
| 단체저자명 | University of Minnesota. Mathematics. |
| 서명/저자사항 | Stochastic Models of Epithelial Cancer Initiation and Glioblastoma Recurrence. |
| 발행사항 | [S.l.] : University of Minnesota., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 167 p. |
| 소장본 주기 | School code: 0130. |
| ISBN | 9780438351264 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Jasmine Foo. |
| 요약 | Cancer development involves the inherently stochastic accumulation of genetic mutations, conferring growth advantages to the cells affected by these mutations. Thus, stochastic modeling provides useful insight when studying the evolutionary proc |
| 요약 | First we explore the temporal dynamics of spatial heterogeneity during the process of carcinogenesis from healthy tissue. We utilize a spatial stochastic model of mutation accumulation and clonal expansion to describe this process. Under a two-s |
| 요약 | Next we study the propagation speed of a premalignant clone during carcinogenesis. We approximate a premalignant clone in epithelial tissue containing w layers of proliferating cells (referred to as a ``basal zone'') with a biased voter model o |
| 요약 | Finally we develop a multi-type branching process model of the tumor progression and treatment response in glioblastoma multiforme (GBM). GBM recurrence is often attributed to acquired resistance to the standard chemotherapeutic agent temozolomi |
| 일반주제명 | Applied mathematics. Biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999380 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00028018 | 519 | 가야대학교// | 대출가능 |
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