| LDR | | 02304nmm uu200433 4500 |
| 001 | | 000000333691 |
| 005 | | 20240805173524 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438351264 |
| 035 | |
▼a (MiAaPQ)AAI10830016 |
| 035 | |
▼a (MiAaPQ)umn:19356 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 519 |
| 100 | 1 |
▼a Storey, Kathleen M. |
| 245 | 10 |
▼a Stochastic Models of Epithelial Cancer Initiation and Glioblastoma Recurrence. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 167 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Jasmine Foo. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a Cancer development involves the inherently stochastic accumulation of genetic mutations, conferring growth advantages to the cells affected by these mutations. Thus, stochastic modeling provides useful insight when studying the evolutionary proc |
| 520 | |
▼a First we explore the temporal dynamics of spatial heterogeneity during the process of carcinogenesis from healthy tissue. We utilize a spatial stochastic model of mutation accumulation and clonal expansion to describe this process. Under a two-s |
| 520 | |
▼a Next we study the propagation speed of a premalignant clone during carcinogenesis. We approximate a premalignant clone in epithelial tissue containing w layers of proliferating cells (referred to as a ``basal zone'') with a biased voter model o |
| 520 | |
▼a Finally we develop a multi-type branching process model of the tumor progression and treatment response in glioblastoma multiforme (GBM). GBM recurrence is often attributed to acquired resistance to the standard chemotherapeutic agent temozolomi |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Applied mathematics. |
| 650 | 4 |
▼a Biology. |
| 690 | |
▼a 0364 |
| 690 | |
▼a 0306 |
| 710 | 20 |
▼a University of Minnesota.
▼b Mathematics. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999380
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |