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Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Shoucri, Bassem Merit. |
| 단체저자명 | University of California, Irvine. Biological Sciences. |
| 서명/저자사항 | Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function. |
| 발행사항 | [S.l.] : University of California, Irvine., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 191 p. |
| 소장본 주기 | School code: 0030. |
| ISBN | 9780438296176 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Includes supplementary digital materials. Adviser: Bruce Blumberg. |
| 요약 | The obesity epidemic has reached unsustainable proportions and threatens to bankrupt the American healthcare system. While physicians continue to prescribe diet and exercise as a panacea for obesity, mounting evidence shows that the majority of |
| 요약 | Mounting evidence implicates early-life exposure to industrial chemicals---of which there are tens of thousands---as an overlooked contributor to the obesity epidemic. Of particular concern are a subset of at least 1,000 chemicals, termed endocr |
| 요약 | Our lab identified and characterized the archetypal obesogen, tributyltin (TBT), which acts through two nuclear receptors, peroxisome proliferator-activated receptor gamma and retinoid X receptor (RXR), to promote the development of fat tissue. |
| 요약 | The work described in this dissertation employs the in vitro MSC adipogenesis model to further explore the molecular mechanisms through which TBT alters the fate and function of developing stem cells. In Chapter 1, we investigate how TBT influ |
| 일반주제명 | Developmental biology. Endocrinology. Molecular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14998339 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00027881 | 574 | 가야대학교// | 대출가능 |
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