| LDR | | 02527nmm uu200469 4500 |
| 001 | | 000000333554 |
| 005 | | 20240805173243 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438296176 |
| 035 | |
▼a (MiAaPQ)AAI10817199 |
| 035 | |
▼a (MiAaPQ)uci:15042 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Shoucri, Bassem Merit. |
| 245 | 10 |
▼a Retinoid X Receptor Activation by the Endocrine Disruptor Tributyltin Promotes Adipose Lineage Commitment and Perturbs Adipocyte Function. |
| 260 | |
▼a [S.l.] :
▼b University of California, Irvine.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 191 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Includes supplementary digital materials. |
| 500 | |
▼a Adviser: Bruce Blumberg. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of California, Irvine, 2018. |
| 520 | |
▼a The obesity epidemic has reached unsustainable proportions and threatens to bankrupt the American healthcare system. While physicians continue to prescribe diet and exercise as a panacea for obesity, mounting evidence shows that the majority of |
| 520 | |
▼a Mounting evidence implicates early-life exposure to industrial chemicals---of which there are tens of thousands---as an overlooked contributor to the obesity epidemic. Of particular concern are a subset of at least 1,000 chemicals, termed endocr |
| 520 | |
▼a Our lab identified and characterized the archetypal obesogen, tributyltin (TBT), which acts through two nuclear receptors, peroxisome proliferator-activated receptor gamma and retinoid X receptor (RXR), to promote the development of fat tissue. |
| 520 | |
▼a The work described in this dissertation employs the in vitro MSC adipogenesis model to further explore the molecular mechanisms through which TBT alters the fate and function of developing stem cells. In Chapter 1, we investigate how TBT influ |
| 590 | |
▼a School code: 0030. |
| 650 | 4 |
▼a Developmental biology. |
| 650 | 4 |
▼a Endocrinology. |
| 650 | 4 |
▼a Molecular biology. |
| 690 | |
▼a 0758 |
| 690 | |
▼a 0409 |
| 690 | |
▼a 0307 |
| 710 | 20 |
▼a University of California, Irvine.
▼b Biological Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0030 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14998339
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |