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The Influence of Mechanical Stimulation and Macromolecular Crowding on Engineered, Scaffoldfree Tendon Fibers

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자료유형	E-Book
개인저자	Mubyana, Kuwabo.
단체저자명	Rensselaer Polytechnic Institute. Biomedical Engineering.
서명/저자사항	The Influence of Mechanical Stimulation and Macromolecular Crowding on Engineered, Scaffoldfree Tendon Fibers.
발행사항	[S.l.] : Rensselaer Polytechnic Institute., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	127 p.
소장본 주기	School code: 0185.
ISBN	9780438206908
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: David T. Corr.
요약	The current standard for treatment of high grade tendon tears is surgical replacement grafts, however they present the challenge of limited tissue availability (allografts and autografts), donor site morbidity (autografts), and immune rejection
요약	Primed with this knowledge, our laboratory has taken a more biomimetic approach to tendon tissue engineering---a scaffold-free approach that is inspired by key aspects of embryonic tendon development. By seeding a high density of cells into a gr
요약	In the first aim of my doctoral thesis, I developed a method to engineer individual scaffold-free tendon fibers using a micro-molded growth channel, which yielded higher throughput, greater consistency, and higher repeatability in the design of
요약	The second aim examined the response of engineered, scaffold-free, dermal fibroblast-derived fibers to mechanical stimulation, namely cyclic uniaxial strain (designed to mimic motion-induced loading in the embryo), and quasi-static strain (to mi
요약	The final aim of this dissertation investigated the influence of macromolecular crowders on the mechanical properties of engineered scaffold-free tendon fibers. Two crowders, dextran sulfate (DsX) and Ficoll-cocktail, were tested. Fiber formatio
요약	This thesis has provided unique insight on the roles of distinct mechanical stimuli and macromolecular crowding on tendon fiber development and maturation. The knowledge gained on cyclic uniaxial strain, quasi-static loading, and Ficoll-conditio
일반주제명	Biomedical engineering.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14997609