| LDR | | 02854nmm uu200433 4500 |
| 001 | | 000000333110 |
| 005 | | 20240805172218 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438206908 |
| 035 | |
▼a (MiAaPQ)AAI10790843 |
| 035 | |
▼a (MiAaPQ)rpi:11314 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 610 |
| 100 | 1 |
▼a Mubyana, Kuwabo. |
| 245 | 14 |
▼a The Influence of Mechanical Stimulation and Macromolecular Crowding on Engineered, Scaffoldfree Tendon Fibers. |
| 260 | |
▼a [S.l.] :
▼b Rensselaer Polytechnic Institute.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 127 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: David T. Corr. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Rensselaer Polytechnic Institute, 2018. |
| 520 | |
▼a The current standard for treatment of high grade tendon tears is surgical replacement grafts, however they present the challenge of limited tissue availability (allografts and autografts), donor site morbidity (autografts), and immune rejection |
| 520 | |
▼a Primed with this knowledge, our laboratory has taken a more biomimetic approach to tendon tissue engineering---a scaffold-free approach that is inspired by key aspects of embryonic tendon development. By seeding a high density of cells into a gr |
| 520 | |
▼a In the first aim of my doctoral thesis, I developed a method to engineer individual scaffold-free tendon fibers using a micro-molded growth channel, which yielded higher throughput, greater consistency, and higher repeatability in the design of |
| 520 | |
▼a The second aim examined the response of engineered, scaffold-free, dermal fibroblast-derived fibers to mechanical stimulation, namely cyclic uniaxial strain (designed to mimic motion-induced loading in the embryo), and quasi-static strain (to mi |
| 520 | |
▼a The final aim of this dissertation investigated the influence of macromolecular crowders on the mechanical properties of engineered scaffold-free tendon fibers. Two crowders, dextran sulfate (DsX) and Ficoll-cocktail, were tested. Fiber formatio |
| 520 | |
▼a This thesis has provided unique insight on the roles of distinct mechanical stimuli and macromolecular crowding on tendon fiber development and maturation. The knowledge gained on cyclic uniaxial strain, quasi-static loading, and Ficoll-conditio |
| 590 | |
▼a School code: 0185. |
| 650 | 4 |
▼a Biomedical engineering. |
| 690 | |
▼a 0541 |
| 710 | 20 |
▼a Rensselaer Polytechnic Institute.
▼b Biomedical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0185 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997609
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |