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Interplay of Host and Pathogen Factors Determines Immunity and Clinical Outcome Following Campylobacter jejuni Infection in Mice

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자료유형	E-Book
개인저자	Brudvig, Jean Marie.
단체저자명	Michigan State University. Comparative Medicine and Integrative Biology - Doctor of Philosophy.
서명/저자사항	Interplay of Host and Pathogen Factors Determines Immunity and Clinical Outcome Following Campylobacter jejuni Infection in Mice.
발행사항	[S.l.] : Michigan State University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	253 p.
소장본 주기	School code: 0128.
ISBN	9780355867060
일반주기	Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B. Adviser: Linda S. Mansfield.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	Campylobacter jejuni is a common cause of bacterial enteritis worldwide, and is associated with the post-infectious neuropathy Guillain-Barre syndrome (GBS). The currently accepted pathogenesis of C. jejuni-associated GBS involves generation of
요약	The model system was developed to exploit both C. jejuni strain differences and immunogenetic biases reported for C57BL/6 and BALB/c mice. C. jejuni strains associated with colitis ( C. jejuni 11168) and GBS (C. jejuni 260.94) were used in combi
요약	BALB/c wild-type and IL-10-/- mice infected with C. jejuni 260.94 were first assessed as a potential GBS model. C57BL/6 IL-10-/- mice infected with C. jejuni 260.94 were previously shown to mount Th2-mediated immunity and produce anti-gangliosi
요약	The second in vivo study was designed to further explore these contrasting immune responses. Both C57BL/6 IL-10-/- and BALB/c IL-10-/- mice were orally infected with colitogenic C. jejuni 11168 or GBS-associated C. jejuni 260.94. Immunity and d
요약	Results of the current studies demonstrate that immunity and disease outcome following C. jejuni infection depend upon the characteristics of both the infecting C. jejuni strain and host genetic background, and implicate DCs as early contributor
일반주제명	Immunology. Microbiology.
언어	영어
기본자료 저록	Dissertation Abstracts International79-09B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T14997743