| LDR | | 02773nmm uu200457 4500 |
| 001 | | 000000333013 |
| 005 | | 20240805172025 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780355867060 |
| 035 | |
▼a (MiAaPQ)AAI10793209 |
| 035 | |
▼a (MiAaPQ)grad.msu:15944 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Brudvig, Jean Marie. |
| 245 | 10 |
▼a Interplay of Host and Pathogen Factors Determines Immunity and Clinical Outcome Following Campylobacter jejuni Infection in Mice. |
| 260 | |
▼a [S.l.] :
▼b Michigan State University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 253 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B. |
| 500 | |
▼a Adviser: Linda S. Mansfield. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Michigan State University, 2018. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a Campylobacter jejuni is a common cause of bacterial enteritis worldwide, and is associated with the post-infectious neuropathy Guillain-Barre syndrome (GBS). The currently accepted pathogenesis of C. jejuni-associated GBS involves generation of |
| 520 | |
▼a The model system was developed to exploit both C. jejuni strain differences and immunogenetic biases reported for C57BL/6 and BALB/c mice. C. jejuni strains associated with colitis ( C. jejuni 11168) and GBS (C. jejuni 260.94) were used in combi |
| 520 | |
▼a BALB/c wild-type and IL-10-/- mice infected with C. jejuni 260.94 were first assessed as a potential GBS model. C57BL/6 IL-10-/- mice infected with C. jejuni 260.94 were previously shown to mount Th2-mediated immunity and produce anti-gangliosi |
| 520 | |
▼a The second in vivo study was designed to further explore these contrasting immune responses. Both C57BL/6 IL-10-/- and BALB/c IL-10-/- mice were orally infected with colitogenic C. jejuni 11168 or GBS-associated C. jejuni 260.94. Immunity and d |
| 520 | |
▼a Results of the current studies demonstrate that immunity and disease outcome following C. jejuni infection depend upon the characteristics of both the infecting C. jejuni strain and host genetic background, and implicate DCs as early contributor |
| 590 | |
▼a School code: 0128. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a Michigan State University.
▼b Comparative Medicine and Integrative Biology - Doctor of Philosophy. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-09B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0128 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997743
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |