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Manipulating Exosome Signaling to Inhibit Tumor Metastasis
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Plebanek, Michael Paul. |
| 단체저자명 | Northwestern University. Life Sciences. |
| 서명/저자사항 | Manipulating Exosome Signaling to Inhibit Tumor Metastasis. |
| 발행사항 | [S.l.] : Northwestern University., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 161 p. |
| 소장본 주기 | School code: 0163. |
| ISBN | 9780438116207 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisers: Colby S. Thaxton |
| 요약 | Over the past decade significant advancements have been made across the field of cancer biology resulting in transformative new therapies. Despite these advancements, treatments for metastatic cancer remain relatively ineffective. Metastasis is |
| 요약 | In this project, we were first interested in understanding the effects of exosomes released from non-metastatic cancer cells. It is well established that exosomes from aggressive cancer cells promote metastasis, but the functions of non-aggressi |
| 요약 | Additionally, due to the metastasis promoting functions of tumor exosomes, we were interested in developing a technology to specifically inhibit the uptake of cancer exosomes by target cells. Exosome uptake is dependent on cholesterol-rich lipid |
| 요약 | The development of HDL NPs led us to test their efficacy as a cancer therapeutic in a wide array of applications. We discovered that HDL NPs can function to inhibit metastasis independent of inhibiting exosome uptake, as well. Myeloid-derived su |
| 일반주제명 | Biology. Oncology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-11B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14997975 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00027066 | 574 | 가야대학교// | 대출가능 |
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