| LDR | | 02294nmm uu200433 4500 |
| 001 | | 000000332739 |
| 005 | | 20240805171509 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438116207 |
| 035 | |
▼a (MiAaPQ)AAI10811362 |
| 035 | |
▼a (MiAaPQ)northwestern:14097 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Plebanek, Michael Paul. |
| 245 | 10 |
▼a Manipulating Exosome Signaling to Inhibit Tumor Metastasis. |
| 260 | |
▼a [S.l.] :
▼b Northwestern University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 161 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B. |
| 500 | |
▼a Advisers: Colby S. Thaxton |
| 502 | 1 |
▼a Thesis (Ph.D.)--Northwestern University, 2018. |
| 520 | |
▼a Over the past decade significant advancements have been made across the field of cancer biology resulting in transformative new therapies. Despite these advancements, treatments for metastatic cancer remain relatively ineffective. Metastasis is |
| 520 | |
▼a In this project, we were first interested in understanding the effects of exosomes released from non-metastatic cancer cells. It is well established that exosomes from aggressive cancer cells promote metastasis, but the functions of non-aggressi |
| 520 | |
▼a Additionally, due to the metastasis promoting functions of tumor exosomes, we were interested in developing a technology to specifically inhibit the uptake of cancer exosomes by target cells. Exosome uptake is dependent on cholesterol-rich lipid |
| 520 | |
▼a The development of HDL NPs led us to test their efficacy as a cancer therapeutic in a wide array of applications. We discovered that HDL NPs can function to inhibit metastasis independent of inhibiting exosome uptake, as well. Myeloid-derived su |
| 590 | |
▼a School code: 0163. |
| 650 | 4 |
▼a Biology. |
| 650 | 4 |
▼a Oncology. |
| 690 | |
▼a 0306 |
| 690 | |
▼a 0992 |
| 710 | 20 |
▼a Northwestern University.
▼b Life Sciences. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-11B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0163 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14997975
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |