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Development of a Positron-Emitting Surrogate Microsphere for Image-Based Dosimetry in Yttrium-90 Radioembolization Therapy

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개인저자Chambers, Gregory D.
단체저자명The University of New Mexico. Nuclear Engineering.
서명/저자사항Development of a Positron-Emitting Surrogate Microsphere for Image-Based Dosimetry in Yttrium-90 Radioembolization Therapy.
발행사항[S.l.] : The University of New Mexico., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항208 p.
소장본 주기School code: 0142.
ISBN9780438227170
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Reed Selwyn.
요약Radioembolization of liver tumors using yttrium-90 (Y-90) labeled microspheres is a proven method of treatment. The primary decay mode of Y-90 is beta-minus decay. The electrons produced during decay deliver a cytotoxic radiation dose in a local
요약This study was performed to create a positron-emitting surrogate microsphere that was close in size and shape to the Y-90 microspheres. Positron emission tomography (PET) is superior to SPECT for activity quantification. Fluorine-18 (F-18) was c
요약Aim 1: To develop surrogate PET microsphere. This included radiolabeling, stability testing in vitro and stability testing in an animal.
요약Aim 2: To develop a computational technique to perform dosimetry with the surrogate microsphere. PET images of the surrogate radionuclide were imported into a Monte Carlo program. PET images were used to simulate the distribution of the Y-90 mic
일반주제명Medicine.
Nuclear physics and radiation.
Medical imaging.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14997554

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