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Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions

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자료유형	E-Book
개인저자	Zegarra Ruiz, Daniel Fernando.
단체저자명	Yale University.
서명/저자사항	Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions.
발행사항	[S.l.] : Yale University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	184 p.
소장본 주기	School code: 0265.
ISBN	9780438269613
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Martin Alexander Kriegel.
요약	Autoimmune diseases are a major health problem affecting over 200 million people worldwide and represent one of the leading causes of death for women under 65 years old. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that
요약	Alterations in the gut microbiota composition have been associated to autoimmune diseases, but it is largely unknown which specific bacterial communities are responsible for these effects. Interestingly, diet has been demonstrated to shape the g
요약	I utilized a spontaneous and inducible lupus model to dissect the role that diet, gut microbiota, and their interactions play in SLE. For the spontaneous model, I worked with toll-like receptor 7 transgenic (TLR7.1 Tg) mice that develop SLE-like
요약	In chapter II, I demonstrate the role that gut microbiota plays on SLE. Fecal 16S rDNA sequencing was performed and I identified that murine SLE models developed intestinal dysbiosis. Depletion of the gut microbiota reduced mortality and pathoge
요약	In chapter III, I identify a key bacterial strain that exacerbates SLE. Through culture of internal organs I revealed that L. reuteri (LR) translocated outside the gut in SLE-prone mice and in cohoused wild type littermates. In addition, 16S rDN
요약	Finally, in chapter IV, I fed a RS enriched diet to our lupus mouse models before onset of disease to assess if diet can ameliorate systemic autoimmunity through modulation of the gut microbiome and LR outgrowth inhibition. Fecal 16S rDNA sequen
요약	In conclusion, the research outline in this thesis contributes to a better understanding of the effects of RS on lupus pathogenesis through modulation of the gut microbiome and suppression of pathobionts, representing a safer approach to amelior
일반주제명	Immunology. Health sciences. Microbiology.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15001245