| LDR | | 03164nmm uu200481 4500 |
| 001 | | 000000332180 |
| 005 | | 20240805170208 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438269613 |
| 035 | |
▼a (MiAaPQ)AAI10957220 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Zegarra Ruiz, Daniel Fernando. |
| 245 | 10 |
▼a Gut Microbiota and Systemic Autoimmunity: Ameliorating Systemic Lupus Erythematosus through Diet, Microbiota, and Host Immune System Interactions. |
| 260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 184 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Martin Alexander Kriegel. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Yale University, 2018. |
| 520 | |
▼a Autoimmune diseases are a major health problem affecting over 200 million people worldwide and represent one of the leading causes of death for women under 65 years old. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that |
| 520 | |
▼a Alterations in the gut microbiota composition have been associated to autoimmune diseases, but it is largely unknown which specific bacterial communities are responsible for these effects. Interestingly, diet has been demonstrated to shape the g |
| 520 | |
▼a I utilized a spontaneous and inducible lupus model to dissect the role that diet, gut microbiota, and their interactions play in SLE. For the spontaneous model, I worked with toll-like receptor 7 transgenic (TLR7.1 Tg) mice that develop SLE-like |
| 520 | |
▼a In chapter II, I demonstrate the role that gut microbiota plays on SLE. Fecal 16S rDNA sequencing was performed and I identified that murine SLE models developed intestinal dysbiosis. Depletion of the gut microbiota reduced mortality and pathoge |
| 520 | |
▼a In chapter III, I identify a key bacterial strain that exacerbates SLE. Through culture of internal organs I revealed that L. reuteri (LR) translocated outside the gut in SLE-prone mice and in cohoused wild type littermates. In addition, 16S rDN |
| 520 | |
▼a Finally, in chapter IV, I fed a RS enriched diet to our lupus mouse models before onset of disease to assess if diet can ameliorate systemic autoimmunity through modulation of the gut microbiome and LR outgrowth inhibition. Fecal 16S rDNA sequen |
| 520 | |
▼a In conclusion, the research outline in this thesis contributes to a better understanding of the effects of RS on lupus pathogenesis through modulation of the gut microbiome and suppression of pathobionts, representing a safer approach to amelior |
| 590 | |
▼a School code: 0265. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Health sciences. |
| 650 | 4 |
▼a Microbiology. |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0566 |
| 690 | |
▼a 0410 |
| 710 | 20 |
▼a Yale University. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0265 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001245
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |