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The Development of Novel Non-Peptide Proteasome Inhibitors for the Treatment of Solid Tumors
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Miller, Zachary C. |
| 단체저자명 | University of Kentucky. |
| 서명/저자사항 | The Development of Novel Non-Peptide Proteasome Inhibitors for the Treatment of Solid Tumors. |
| 발행사항 | [S.l.] : University of Kentucky., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 143 p. |
| 소장본 주기 | School code: 0102. |
| ISBN | 9780438239180 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Kyung Bo Kim. |
| 요약 | The proteasome is a large protein complex which is responsible for the majority of protein degradation in eukaryotes. Following FDA approval of the first proteasome inhibitor bortezomib for the treatment of multiple myeloma (MM) in 2003, there h |
| 요약 | It is our hypothesis that compounds with non-peptidic structures, non-covalent and reversible modes of action, and unique selectivity profiles against the proteasome's distinct catalytic subunits could have superior pharmacodynamic and pharmacok |
| 요약 | Our efforts began with a computational screen performed in the lab of Dr. Chang-Guo Zhan. This virtual screen narrowed a library of over 300,000 drug-like compounds down to under 300 virtual hits which were then screened for proteasome inhibitor |
| 요약 | We believe that our lead compound as well as our drug discovery approach itself will be of interest and use to other researchers. We hope that this research effort may aid in the further development of reversible non-peptide proteasome inhibitor |
| 일반주제명 | Pharmaceutical sciences. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15001222 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00026484 | 615 | 가야대학교/전자책서버(컴퓨터서버)/ | 대출가능 |
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