| LDR | | 02226nmm uu200397 4500 |
| 001 | | 000000332157 |
| 005 | | 20240805170139 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438239180 |
| 035 | |
▼a (MiAaPQ)AAI10954429 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 615 |
| 100 | 1 |
▼a Miller, Zachary C. |
| 245 | 14 |
▼a The Development of Novel Non-Peptide Proteasome Inhibitors for the Treatment of Solid Tumors. |
| 260 | |
▼a [S.l.] :
▼b University of Kentucky.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 143 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Kyung Bo Kim. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Kentucky, 2018. |
| 520 | |
▼a The proteasome is a large protein complex which is responsible for the majority of protein degradation in eukaryotes. Following FDA approval of the first proteasome inhibitor bortezomib for the treatment of multiple myeloma (MM) in 2003, there h |
| 520 | |
▼a It is our hypothesis that compounds with non-peptidic structures, non-covalent and reversible modes of action, and unique selectivity profiles against the proteasome's distinct catalytic subunits could have superior pharmacodynamic and pharmacok |
| 520 | |
▼a Our efforts began with a computational screen performed in the lab of Dr. Chang-Guo Zhan. This virtual screen narrowed a library of over 300,000 drug-like compounds down to under 300 virtual hits which were then screened for proteasome inhibitor |
| 520 | |
▼a We believe that our lead compound as well as our drug discovery approach itself will be of interest and use to other researchers. We hope that this research effort may aid in the further development of reversible non-peptide proteasome inhibitor |
| 590 | |
▼a School code: 0102. |
| 650 | 4 |
▼a Pharmaceutical sciences. |
| 690 | |
▼a 0572 |
| 710 | 20 |
▼a University of Kentucky. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0102 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001222
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |