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Childhood Emotional Abuse and Neuroendocrine Stress Systems in Depression: A Possible Role for Corticomotor Circuitry

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개인저자Frost, Carlton P., VI.
단체저자명The University of Wisconsin - Madison. Neuroscience.
서명/저자사항Childhood Emotional Abuse and Neuroendocrine Stress Systems in Depression: A Possible Role for Corticomotor Circuitry.
발행사항[S.l.] : The University of Wisconsin - Madison., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항121 p.
소장본 주기School code: 0262.
ISBN9780438079281
일반주기 Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisers: Heather C. Abercrombie
요약The activity of neuroendocrine stress systems, and their effects on memory formation & neuroplasticity, are altered in depression. Research in animal models shows early life adversity alters corticosteroids' effects on memory formation and neuro
요약In a double-blind crossover study, functional magnetic resonance imaging (fMRI) was used to assess the neural correlates of the effects of cortisol administration (CORT), vs Placebo, on memory formation for emotional pictures. In addition, I use
요약Only in women with history of severe EA, CORT eliminated the relation between depression severity and negative memory bias by normalizing recall for pleasant stimuli. These women showed a related increase in BOLD activation in cortical premotor
요약Thus, I demonstrate evidence of distinct neurocognitive responses to acute cortisol elevation in depressed women with history of EA, who may comprise an etiologically distinct subtype of depression, and whose emotional learning is partly normali
일반주제명Neurosciences.
Psychology.
Endocrinology.
언어영어
기본자료 저록Dissertation Abstracts International79-11B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T14999296

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