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Mammary Epithelial Cell Fate & EGFR-Rasgrpl-Ras Effector Signals
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Samocha, Alexandr Joseph. |
| 단체저자명 | University of California, San Francisco. Biomedical Sciences. |
| 서명/저자사항 | Mammary Epithelial Cell Fate & EGFR-Rasgrpl-Ras Effector Signals. |
| 발행사항 | [S.l.] : University of California, San Francisco., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 209 p. |
| 소장본 주기 | School code: 0034. |
| ISBN | 9780438250239 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Advisers: Jeroen P. Roose |
| 요약 | Mammary stem cells (MaSC) are a heterogeneous population that give rise to progenitor cells subsequently developing into differentiated cells. The exact mammary epithelial cell (MEC) hierarchy and particularly the signals that govern this hierar |
| 요약 | We demonstrate that RasGEF Rasgrp1 is expressed in mammary epithelium and use cleared fat pad approaches to reveal a previously unrecognized functional role for RasGRP1 in the mammary gland. These approaches involved the transplantation of mamma |
| 요약 | Functionally, Rasgrp1 perturbation led to shortened mammary ductal trees in mammary whole mounts, increases in numbers of proliferative terminal end buds (TEBs), and sustained proliferation of mammary ductal cells (with high phospho-Akt) in area |
| 요약 | MEC colony assays using Rasgrp1-/- and Rasgrp1Anaef cells revealed that progenitors form more and larger colonies than WT counterparts and with increased proliferation (Ki67) in response to EGF and strong staining for pAkt, all of which were re |
| 요약 | In sum, we provide mechanistic insights on the biochemical signals that impact MACSs and progenitor cells. We show that Rasgrp1 is required to balance MEC EGFR signals and regulate mammary stem and progenitor cell fate to dampen proliferation so |
| 일반주제명 | Developmental biology. Cellular biology. Molecular biology. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14998896 |
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인쇄
| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00026249 | 574 | 가야대학교// | 대출가능 |
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