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Pattern Separation in the Hippocampus, in Health and Epilepsy
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Madar, Antoine David. |
| 단체저자명 | The University of Wisconsin - Madison. Neuroscience. |
| 서명/저자사항 | Pattern Separation in the Hippocampus, in Health and Epilepsy. |
| 발행사항 | [S.l.] : The University of Wisconsin - Madison., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 313 p. |
| 소장본 주기 | School code: 0262. |
| ISBN | 9780438379176 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Adviser: Mathew V. Jones. |
| 요약 | Pattern separation is the neuronal computation posited to support our ability to store similar experiences as distinct memory traces. The dentate gyrus (DG) of the hippocampus is generally thought to perform this process, transforming similar co |
| 요약 | Using the ability to directly control inputs and measure outputs afforded by slice electrophysiology (in mice), I first showed that the isolated DG circuitry decorrelates non-simultaneous input spiketrains at the level of single granule cells (G |
| 요약 | Second, I investigated other forms of pattern separation by considering diverse neural codes that imply different definitions of the similarity between spiketrains. Results demonstrate that the DG can perform pattern separation using multiplexed |
| 요약 | I finally examined how TLE affects DG pattern separation. Behavioral experiments in humans and mice first determined that TLE is characterized by deficits in mnemonic discrimination, the cognitive function purportedly supported by pattern separa |
| 요약 | Overall, my dissertation shows that pattern separation can be performed in the DG through different neural codes, and that the impairment of these neuronal computations is correlated with mnemonic confusion, implicating the DG in TLE as a critic |
| 일반주제명 | Neurosciences. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-02B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15001189 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00026086 | 616 | 가야대학교// | 대출가능 |
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