| LDR | | 02548nmm uu200421 4500 |
| 001 | | 000000331759 |
| 005 | | 20240805165315 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438379176 |
| 035 | |
▼a (MiAaPQ)AAI10935228 |
| 035 | |
▼a (MiAaPQ)wisc:15783 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Madar, Antoine David. |
| 245 | 10 |
▼a Pattern Separation in the Hippocampus, in Health and Epilepsy. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 313 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B. |
| 500 | |
▼a Adviser: Mathew V. Jones. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a Pattern separation is the neuronal computation posited to support our ability to store similar experiences as distinct memory traces. The dentate gyrus (DG) of the hippocampus is generally thought to perform this process, transforming similar co |
| 520 | |
▼a Using the ability to directly control inputs and measure outputs afforded by slice electrophysiology (in mice), I first showed that the isolated DG circuitry decorrelates non-simultaneous input spiketrains at the level of single granule cells (G |
| 520 | |
▼a Second, I investigated other forms of pattern separation by considering diverse neural codes that imply different definitions of the similarity between spiketrains. Results demonstrate that the DG can perform pattern separation using multiplexed |
| 520 | |
▼a I finally examined how TLE affects DG pattern separation. Behavioral experiments in humans and mice first determined that TLE is characterized by deficits in mnemonic discrimination, the cognitive function purportedly supported by pattern separa |
| 520 | |
▼a Overall, my dissertation shows that pattern separation can be performed in the DG through different neural codes, and that the impairment of these neuronal computations is correlated with mnemonic confusion, implicating the DG in TLE as a critic |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Neuroscience. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-02B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001189
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |