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Differential Effects of Repeated Low-dose Ketamine on Cross-frequency Interactions in Naive and Preclinical Models of Movement Disorders

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개인저자Ye, Tony.
단체저자명The University of Arizona. Psychology.
서명/저자사항Differential Effects of Repeated Low-dose Ketamine on Cross-frequency Interactions in Naive and Preclinical Models of Movement Disorders.
발행사항[S.l.] : The University of Arizona., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항190 p.
소장본 주기School code: 0009.
ISBN9780438346093
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Stephen L. Cowen.
요약Ketamine is a well-established anesthetic in high-doses that has been in use for over 50 years (Domino et al., 1965). At low sub-anesthetic doses, ketamine is therapeutically effective at treating a wide range of disorders such as treatment-resi
요약Furthermore, ketamine may also have a therapeutic role in treating Parkinson's disease (PD). Hypersynchronous beta (15 -- 30 Hz) is the pathological oscillatory signature of PD. Additionally, gamma oscillations are pro-kinetic and voluntary move
요약Using the experimental protocols of Bartlett and colleagues (2016) with the addition of measuring local-field potential activity, we show that the pathological oscillations associated with Parkinson's disease (e.g., beta (15 -- 30 Hz)) in 6-hydr
요약Ketamine does produce differential effects on cross-frequency interactions. Ketamine enhanced coordination between low and high frequencies in the striatum, but with the opposite effect in the hippocampus. In LID animals, ketamine reverses theta
일반주제명Neurosciences.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15001116

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