| LDR | | 02315nmm uu200409 4500 |
| 001 | | 000000331694 |
| 005 | | 20240805164915 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438346093 |
| 035 | |
▼a (MiAaPQ)AAI10932844 |
| 035 | |
▼a (MiAaPQ)arizona:16644 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616 |
| 100 | 1 |
▼a Ye, Tony. |
| 245 | 10 |
▼a Differential Effects of Repeated Low-dose Ketamine on Cross-frequency Interactions in Naive and Preclinical Models of Movement Disorders. |
| 260 | |
▼a [S.l.] :
▼b The University of Arizona.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 190 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Stephen L. Cowen. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Arizona, 2018. |
| 520 | |
▼a Ketamine is a well-established anesthetic in high-doses that has been in use for over 50 years (Domino et al., 1965). At low sub-anesthetic doses, ketamine is therapeutically effective at treating a wide range of disorders such as treatment-resi |
| 520 | |
▼a Furthermore, ketamine may also have a therapeutic role in treating Parkinson's disease (PD). Hypersynchronous beta (15 -- 30 Hz) is the pathological oscillatory signature of PD. Additionally, gamma oscillations are pro-kinetic and voluntary move |
| 520 | |
▼a Using the experimental protocols of Bartlett and colleagues (2016) with the addition of measuring local-field potential activity, we show that the pathological oscillations associated with Parkinson's disease (e.g., beta (15 -- 30 Hz)) in 6-hydr |
| 520 | |
▼a Ketamine does produce differential effects on cross-frequency interactions. Ketamine enhanced coordination between low and high frequencies in the striatum, but with the opposite effect in the hippocampus. In LID animals, ketamine reverses theta |
| 590 | |
▼a School code: 0009. |
| 650 | 4 |
▼a Neurosciences. |
| 690 | |
▼a 0317 |
| 710 | 20 |
▼a The University of Arizona.
▼b Psychology. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0009 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15001116
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |