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Tissue Engineering of Cervical Intervertebral Discs: An in vitro and in vivo Pre-clinical Canine Model of Total Disc Replacement

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개인저자Mojica Santiago, Jorge Alexis.
단체저자명Cornell University. Biomedical Engineering.
서명/저자사항Tissue Engineering of Cervical Intervertebral Discs: An in vitro and in vivo Pre-clinical Canine Model of Total Disc Replacement.
발행사항[S.l.] : Cornell University., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항188 p.
소장본 주기School code: 0058.
ISBN9780438345362
일반주기 Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Lawrence Bonassar.
요약Degeneration of the intervertebral disc (IVD) is directly associated with the leading causes of disability in the industrialized world, neck and back pain. Current treatments focus on pain relief and mitigating symptoms rather than addressing th
요약Total disc replacement with biological tissue-engineered IVDs (TE-IVDs) has only been tested in small animal models to date. This dissertation sought to address the need for a larger animal model that is clinically relevant to humans by demonstr
요약Despite the favorable outcomes in stably implanted TE-IVDs, new challenges were identified in the canine model that had not been encountered in rodents before. Segment instability caused 50% of TE-IVDs to displace out of the disc space upon impl
일반주제명Biomedical engineering.
Biomechanics.
Biology.
언어영어
기본자료 저록Dissertation Abstracts International80-01B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000960

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