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Chemical Biology Approaches for Modulating Proteostasis and Cellular Processes

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자료유형	E-Book
개인저자	Salami, Jemilat.
단체저자명	Yale University.
서명/저자사항	Chemical Biology Approaches for Modulating Proteostasis and Cellular Processes.
발행사항	[S.l.] : Yale University., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	179 p.
소장본 주기	School code: 0265.
ISBN	9780438194687
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Craig M. Crews.
이용제한사항	This item is not available from ProQuest Dissertations & Theses.
요약	The field of chemical genetics has provided researchers with a variety of tools for perturbing and probing intracellular processes in order to better understand the mechanisms that regulate these vital processes. In this work, I describe the way
요약	Chapter 1 of this thesis provides an introduction to the chemical genetics approach and discusses the use of natural products and synthetic probes to perturb intracellular processes for novel biological discovery and therapeutic applications. It
요약	Chapter 2 is a detailed description of our efforts to expand on the advantages of a protein degradation strategy i.e. PROteolysis TArgeting Chimeras (PROTACs) over traditional inhibition as a therapeutic approach. Here, we use the androgen recep
요약	Chapter 3 focuses on my work to characterize and explore the activities of derivatives of the natural product naamidine A. Previous work in the lab had identified two derivatives NA14 and NA15 that alter the activity of IRE1alpha, a critical pro
요약	The findings from this work provide a small glimpse into the wide variety of ways that chemical genetics tools are being used to further biological discovery and develop novel therapeutic strategies.
일반주제명	Molecular biology. Biochemistry.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15000854