| LDR | | 02533nmm uu200445 4500 |
| 001 | | 000000331434 |
| 005 | | 20240805164356 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438194687 |
| 035 | |
▼a (MiAaPQ)AAI10927898 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 574 |
| 100 | 1 |
▼a Salami, Jemilat. |
| 245 | 10 |
▼a Chemical Biology Approaches for Modulating Proteostasis and Cellular Processes. |
| 260 | |
▼a [S.l.] :
▼b Yale University.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 179 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Craig M. Crews. |
| 502 | 1 |
▼a Thesis (Ph.D.)--Yale University, 2018. |
| 506 | |
▼a This item is not available from ProQuest Dissertations & Theses. |
| 520 | |
▼a The field of chemical genetics has provided researchers with a variety of tools for perturbing and probing intracellular processes in order to better understand the mechanisms that regulate these vital processes. In this work, I describe the way |
| 520 | |
▼a Chapter 1 of this thesis provides an introduction to the chemical genetics approach and discusses the use of natural products and synthetic probes to perturb intracellular processes for novel biological discovery and therapeutic applications. It |
| 520 | |
▼a Chapter 2 is a detailed description of our efforts to expand on the advantages of a protein degradation strategy i.e. PROteolysis TArgeting Chimeras (PROTACs) over traditional inhibition as a therapeutic approach. Here, we use the androgen recep |
| 520 | |
▼a Chapter 3 focuses on my work to characterize and explore the activities of derivatives of the natural product naamidine A. Previous work in the lab had identified two derivatives NA14 and NA15 that alter the activity of IRE1alpha, a critical pro |
| 520 | |
▼a The findings from this work provide a small glimpse into the wide variety of ways that chemical genetics tools are being used to further biological discovery and develop novel therapeutic strategies. |
| 590 | |
▼a School code: 0265. |
| 650 | 4 |
▼a Molecular biology. |
| 650 | 4 |
▼a Biochemistry. |
| 690 | |
▼a 0307 |
| 690 | |
▼a 0487 |
| 710 | 20 |
▼a Yale University. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0265 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000854
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |