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The Innate Effector Programmes of Invariant Natural Killer T-Cells

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자료유형E-Book
개인저자Sharma, Akshat.
단체저자명The University of Wisconsin - Madison. Comparative Biomedical Science.
서명/저자사항The Innate Effector Programmes of Invariant Natural Killer T-Cells.
발행사항[S.l.] : The University of Wisconsin - Madison., 2018
발행사항Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항116 p.
소장본 주기School code: 0262.
ISBN9780438292437
일반주기 Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Jenny E. Gumperz.
요약T-cell effector functions exemplify adaptive immunity in that they 'adapt' to the threat at hand via a programme of antigen recognition, clonal expansion and subsequent contraction, and the generation of long-lived memory cells as insurance agai
요약For the former, we stimulated clonal or short-term polyclonal lines of human iNKT cells with plate-bound ICAM-1-Fc in the absence of antigen-presenting cells, but in the presence or absence of exogenous IL-12p70 to investigate the role that LFA-
요약Immunotherapy work was performed within an in vivo model of EBV-driven lymphomagenesis using humanised mice. iNKT cells appear to promote tumour clearance via the activation of endogenous MHC-restricted T-cells. Whether or not the iNKT-TCR is in
요약Ultimately, the work curated here builds a case for the versatility of iNKT cells via their ability to be sensitive to changes in their milieu that do not always involve direct antigen presentation. This ability to 'stay current' is what posits
일반주제명Immunology.
Pathology.
Virology.
언어영어
기본자료 저록Dissertation Abstracts International79-12B(E).
Dissertation Abstract International
대출바로가기http://www.riss.kr/pdu/ddodLink.do?id=T15000996

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