| LDR | | 02400nmm uu200457 4500 |
| 001 | | 000000331347 |
| 005 | | 20240805164213 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438292437 |
| 035 | |
▼a (MiAaPQ)AAI10930600 |
| 035 | |
▼a (MiAaPQ)wisc:15634 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 616.079 |
| 100 | 1 |
▼a Sharma, Akshat. |
| 245 | 14 |
▼a The Innate Effector Programmes of Invariant Natural Killer T-Cells. |
| 260 | |
▼a [S.l.] :
▼b The University of Wisconsin - Madison.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 116 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. |
| 500 | |
▼a Adviser: Jenny E. Gumperz. |
| 502 | 1 |
▼a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018. |
| 520 | |
▼a T-cell effector functions exemplify adaptive immunity in that they 'adapt' to the threat at hand via a programme of antigen recognition, clonal expansion and subsequent contraction, and the generation of long-lived memory cells as insurance agai |
| 520 | |
▼a For the former, we stimulated clonal or short-term polyclonal lines of human iNKT cells with plate-bound ICAM-1-Fc in the absence of antigen-presenting cells, but in the presence or absence of exogenous IL-12p70 to investigate the role that LFA- |
| 520 | |
▼a Immunotherapy work was performed within an in vivo model of EBV-driven lymphomagenesis using humanised mice. iNKT cells appear to promote tumour clearance via the activation of endogenous MHC-restricted T-cells. Whether or not the iNKT-TCR is in |
| 520 | |
▼a Ultimately, the work curated here builds a case for the versatility of iNKT cells via their ability to be sensitive to changes in their milieu that do not always involve direct antigen presentation. This ability to 'stay current' is what posits |
| 590 | |
▼a School code: 0262. |
| 650 | 4 |
▼a Immunology. |
| 650 | 4 |
▼a Pathology. |
| 650 | 4 |
▼a Virology. |
| 690 | |
▼a 0982 |
| 690 | |
▼a 0571 |
| 690 | |
▼a 0720 |
| 710 | 20 |
▼a The University of Wisconsin - Madison.
▼b Comparative Biomedical Science. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 79-12B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0262 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T15000996
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |