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Charge Engineering of Alternative Protein Scaffolds for Molecular Imaging
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Case, Brett Alynn. |
| 단체저자명 | University of Minnesota. Chemical Engineering. |
| 서명/저자사항 | Charge Engineering of Alternative Protein Scaffolds for Molecular Imaging. |
| 발행사항 | [S.l.] : University of Minnesota., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 140 p. |
| 소장본 주기 | School code: 0130. |
| ISBN | 9780438351806 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
Adviser: Benjamin J. Hackel. |
| 요약 | Molecular imaging is a powerful, noninvasive technique for patient stratification and treatment monitoring via cancer biomarker characterization with reporter probes. Small scaffold proteins that combine stable frameworks with diversifiable para |
| 요약 | In this thesis work we enlisted affibody and Gp2 proteins as molecular imaging scaffolds, applied discrete protein engineering designs to modify charge density and distribution, and evaluated promising charge-modified variants as positron emissi |
| 요약 | Preclinical investigation of lead anti-EGFR affibody and Gp2 clones and their charge-varied homologs in mice bearing EGFRhigh and EGFRlow tumor xenografts exposed differences in clonal biodistribution, tumor targeting, and proteolytic stability. |
| 요약 | Collectively, this work provides a suite of tools to maintain and enhance protein function through ionic charge engineering and reveals two promising probes for cancer characterization through molecular recognition of EGFR. |
| 일반주제명 | Chemical engineering. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International80-01B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T14999635 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00025481 | 660 | 가야대학교// | 대출가능 |
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