| LDR | | 02248nmm uu200409 4500 |
| 001 | | 000000331154 |
| 005 | | 20240805163528 |
| 008 | | 181129s2018 |||||||||||||||||c||eng d |
| 020 | |
▼a 9780438351806 |
| 035 | |
▼a (MiAaPQ)AAI10838479 |
| 035 | |
▼a (MiAaPQ)umn:19438 |
| 040 | |
▼a MiAaPQ
▼c MiAaPQ
▼d 248032 |
| 082 | 0 |
▼a 660 |
| 100 | 1 |
▼a Case, Brett Alynn. |
| 245 | 10 |
▼a Charge Engineering of Alternative Protein Scaffolds for Molecular Imaging. |
| 260 | |
▼a [S.l.] :
▼b University of Minnesota.,
▼c 2018 |
| 260 | 1 |
▼a Ann Arbor :
▼b ProQuest Dissertations & Theses,
▼c 2018 |
| 300 | |
▼a 140 p. |
| 500 | |
▼a Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B. |
| 500 | |
▼a Adviser: Benjamin J. Hackel. |
| 502 | 1 |
▼a Thesis (Ph.D.)--University of Minnesota, 2018. |
| 520 | |
▼a Molecular imaging is a powerful, noninvasive technique for patient stratification and treatment monitoring via cancer biomarker characterization with reporter probes. Small scaffold proteins that combine stable frameworks with diversifiable para |
| 520 | |
▼a In this thesis work we enlisted affibody and Gp2 proteins as molecular imaging scaffolds, applied discrete protein engineering designs to modify charge density and distribution, and evaluated promising charge-modified variants as positron emissi |
| 520 | |
▼a Preclinical investigation of lead anti-EGFR affibody and Gp2 clones and their charge-varied homologs in mice bearing EGFRhigh and EGFRlow tumor xenografts exposed differences in clonal biodistribution, tumor targeting, and proteolytic stability. |
| 520 | |
▼a Collectively, this work provides a suite of tools to maintain and enhance protein function through ionic charge engineering and reveals two promising probes for cancer characterization through molecular recognition of EGFR. |
| 590 | |
▼a School code: 0130. |
| 650 | 4 |
▼a Chemical engineering. |
| 690 | |
▼a 0542 |
| 710 | 20 |
▼a University of Minnesota.
▼b Chemical Engineering. |
| 773 | 0 |
▼t Dissertation Abstracts International
▼g 80-01B(E). |
| 773 | |
▼t Dissertation Abstract International |
| 790 | |
▼a 0130 |
| 791 | |
▼a Ph.D. |
| 792 | |
▼a 2018 |
| 793 | |
▼a English |
| 856 | 40 |
▼u http://www.riss.kr/pdu/ddodLink.do?id=T14999635
▼n KERIS |
| 980 | |
▼a 201812
▼f 2019 |
| 990 | |
▼a 관리자 |