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Progressing Mechanobiology from a Simplified to a More Complex System: Development of Novel Platforms and Investigation of Actin Cytoskeletal Remodeling
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| 자료유형 | E-Book |
|---|---|
| 개인저자 | Ho, Kenneth Kwun Yin. |
| 단체저자명 | University of Michigan. Mechanical Engineering. |
| 서명/저자사항 | Progressing Mechanobiology from a Simplified to a More Complex System: Development of Novel Platforms and Investigation of Actin Cytoskeletal Remodeling. |
| 발행사항 | [S.l.] : University of Michigan., 2018 |
| 발행사항 | Ann Arbor : ProQuest Dissertations & Theses, 2018 |
| 형태사항 | 149 p. |
| 소장본 주기 | School code: 0127. |
| ISBN | 9780438126473 |
| 일반주기 |
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Adviser: Allen Po-Chih Liu. |
| 요약 | Compression is a common mechanical stimulus in our body that results from gravity and tissue growth. Inability for cells to maintain force homeostasis can lead to various diseases, and cells may experience an increase in compressive stress in di |
| 요약 | First, I developed an approach that combines purified actin cytoskeletal proteins or mammalian cell-free expression and ultra-thin double emulsion template for constructing a simplified model of a cell through in vitro reconstitution. This was u |
| 요약 | I also developed a pneumatic-controlled, two-layered microfluidic platform for applying compression and aspiration to double emulsion droplets as a model cell. I further improved the microfluidic device to apply controlled compression to single |
| 요약 | Finally, I investigated actin cytoskeletal remodeling, mechanosensing and mechanotransduction of epithelial cells under compression, in a 2D cell population context. I discovered the formation of actin protrusions at the apical surface of the ce |
| 요약 | In this dissertation, I developed experimental platforms and studied the remodeling of actin networks under compression using in vitro reconstitution, single-cell and cell population systems, taking advantages of each experimental system. The p |
| 일반주제명 | Mechanical engineering. |
| 언어 | 영어 |
| 기본자료 저록 | Dissertation Abstracts International79-12B(E). Dissertation Abstract International |
| 대출바로가기 | http://www.riss.kr/pdu/ddodLink.do?id=T15000541 |
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| No. | 등록번호 | 청구기호 | 소장처 | 도서상태 | 반납예정일 | 예약 | 서비스 | 매체정보 |
|---|---|---|---|---|---|---|---|---|
| 1 | WE00025183 | 621 | 가야대학교// | 대출가능 |
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