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Bacterial Mechanosensitive Channel of Large Conductance (MscL) in Mammalian Cells for Novel Mechanobiology Applications

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자료유형	E-Book
개인저자	Heureaux-Torres, Johanna L.
단체저자명	University of Michigan. Mechanical Engineering.
서명/저자사항	Bacterial Mechanosensitive Channel of Large Conductance (MscL) in Mammalian Cells for Novel Mechanobiology Applications.
발행사항	[S.l.] : University of Michigan., 2018
발행사항	Ann Arbor : ProQuest Dissertations & Theses, 2018
형태사항	99 p.
소장본 주기	School code: 0127.
ISBN	9780438126459
일반주기	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B. Adviser: Allen Po-Chih Liu.
요약	Mechanobiology, a relatively young field that centers on how external physical forces on cells or tissues and their intrinsic mechanical properties can influence physiology and disease, has become a pillar in cell biology. Indeed, cells experien
요약	Mechanotransduction at the cellular-scale has perceptible, large-scale implications such as proper organism development, our ability to sense sound and touch, function and homeostasis of organ systems, and disease progression. Previous work in m
요약	Here we demonstrate how the functional expression of the E. coli membrane tension gated mechanosensitive channel of large conductance (MscL) in mammalian cells endows the cells with new mechano-sensing capabilities such as the activation of Msc
요약	The first major contribution in this thesis was to show that MscL can be expressed in mammalian cells, localize to cellular membranes, and responds to membrane tension via osmotic down-shock. The second contribution was demonstrating that the ac
요약	Lastly, we investigated the effect of MscL mechanotransduction on the cell function of migration in cancer metastasis and then more specifically, 3D-confinements. Our findings in our in vivo mouse model showed that there was a marked reduction i
요약	Implications of this thesis are that MscL: (1) can be used as a molecular delivery tool for live-cells via mechanical stimulus
일반주제명	Mechanical engineering.
언어	영어
기본자료 저록	Dissertation Abstracts International79-12B(E). Dissertation Abstract International
대출바로가기	http://www.riss.kr/pdu/ddodLink.do?id=T15000539